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Why? Who? What?...
The National Center for Biotechnology Information (NCBI) recently announced '1,000 prokaryotic genomes are now completed and available in the Genome database'. The increasing trend will provide us with thousands of sequenced organisms over the next years. However, this is only the first step in understanding how cells survive, reproduce and adapt their behavior while being exposed to changing environmental conditions. Complex molecular regulation mechanisms are responsible fort his task, such as transcriptional gene regulatory interactions. Thus, the large-scale reconstruction and analysis of the emerging molecular biological networks is one of the most important tasks in modern Systems Biology and of immense importance for biotechnology and human medicine but cost-intensive, time-consuming, and impossible to perform for any species separately.
The Computational Systems Biology group develops techniques for the analysis of all relevant components of these networks including tools for their reconstruction. This comprises methods based on the DNA sequence, such as remote homology detection and transcription factor binding motif discovery, as well as network-based approaches, such as inter-species transfers of knowledge about gene regulatory networks. We also develop methods for the online identification of case-specific key pathways, word-sense disambiguation in biomedical texts, and clustering problems. In addition to typical systems biology questions, we also develop integrated methods for the analysis and classification of medical metabolome data gathered with ion mobility spectrometry data.
The research group is
headed by Jan Baumbach. Jan moved in March 2010 from
the ICSI
, UC Berkeley.
The picture shows the members of the CSB group. Check People for their web sites. Wonder if we have fun at work? Move your mouse over the picture. :-)
Please follow the links below for more information regarding our group:
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